Inverse relationship between onset and duration of EEG effects of six peripherally administered peptides.
Miller. L H LH; Kastin. A J AJ; Hayes. M M; Sterste. A A; Garcia. J J; Coy. D H DH
Key Findings
- Peripheral injection of DSIP (and other peptides) changes EEG activity in rats.
- The onset of the EEG effect varies between about 14 and 21 minutes after injection.
- Longer latency to the effect is linked to a shorter overall duration of the EEG change.
Practical Outcomes
- For biohackers, this suggests that DSIP taken peripherally may take 15‑20 minutes to kick in, and the effect may be brief if it starts later. It hints that timing of dosing could influence how long the benefit lasts, but the data are from rats and not directly transferable to humans.
Summary
In rats, giving DSIP and similar peptides by injection caused changes in brain waves. The sooner the effect started after the injection, the shorter it lasted. This inverse link between start time and duration was seen at two different dose levels.
Abstract
Electrical activity in the rat brain after the peripheral injection of equimolar (0.1 mM) doses of Metenkephalin, Leu-enkephalin, beta-endorphin, gamma-endorphin, DSIP, and alpha-MSH was assessed by power spectral analysis. The mean onset of EEG activity for each peptide varied between 13.7 and 20.7 minutes and lasted between 27.8 and 40.8 minutes. The significant (p less than 0.001) interaction between duration and latency revealed that the longer the latency, the shorter the duration. Similar findings were observed after injection of the same peptides at a fixed dose of 80 microgram/kg body weight. Thus, the results demonstrate that peripherally injected peptides can exert EEG effects that last longer the sooner they start.
Study Information
pubmed
1981
10.1016/0091-3057(81)90040-x