[Influence of delta-sleep peptide on the enzymes activity of mitochondrial electron transport chain in various rat tissues during aging of the organism].
Bondarenko. T I TI; Kutilin. D S DS; Mikhaleva. I I II
Key Findings
- Sub‑cutaneous DSIP (100 µg/kg) given 5 consecutive days per month stabilised NADH‑dehydrogenase activity in mitochondrial fractions of multiple rat tissues across ages 2‑24 months.
- The treatment was associated with an increased capacity of the antioxidant system, suggesting reduced production of free radicals.
- Activity of succinate dehydrogenase was unchanged, indicating a selective effect on mitochondrial enzymes.
Practical Outcomes
- DSIP may have potential to support mitochondrial function and antioxidant defenses during aging, but the evidence is limited to rats and no human dosing or safety data exist. Biohackers should treat this as a preliminary finding and await further research before incorporating DSIP into longevity protocols.
Summary
In rats, giving delta‑sleep‑inducing peptide (DSIP) under the skin once a month for five days helped keep a key mitochondrial enzyme (NADH‑dehydrogenase) stable as they aged, which might lower harmful free‑radical damage.
Abstract
It is shown that subcutaneous injection of exogenous delta-sleep inducing peptide (DSIP) to rats aged 2-24 months in a dose of 100 μg/kg animal body weight by courses of 5 consecutive days per month has a stabilizing effect on the NADH-dehydrogenase activity in the mitochondrial fractions of various tissues, which together with increasing capacity of the antioxidant system should reduce the production of free radicals and their adverse action on cells macromolecule, herewith the activity of succinate dehydrogenase did not change.
Study Information
pubmed
2014