[Effect of delta-sleep inducing peptide preparation Deltaran on longevity, physiological functions, and carcinogenesis in mice].
Voĭtenkov. V B VB; Popovich. I G IG; Zabezhinskiĭ. M A MA; Iurova. M A MA; Piskunova. T A TA; Mikhaleva. I I II
Key Findings
- The longest‑living 10% of DSIP‑treated mice lived 16% longer than untreated controls.
- Treated mice showed higher vertical activity from 6 months of age until death.
- In anxiety‑related maze tests, DSIP mice spent 73% more time in open arms and explored maze extremities nine times more often.
- Spontaneous tumor development was slowed in the DSIP group.
Practical Outcomes
- The results are interesting but come from a single animal model using high, sub‑cutaneous doses that are not directly translatable to humans. Biohackers should view this as preliminary evidence that DSIP might have geroprotective or anxiolytic potential, but more human safety and dosing data are needed before any real‑world protocol can be recommended.
Summary
In a mouse study, giving the peptide DSIP (as the commercial mix Deltaran) once a month for five days, for the whole life of the animals, made the oldest 10% of the females live about 16% longer. Those mice also stayed more active, were less anxious in maze tests, and showed slower natural tumor development, suggesting possible anti‑aging, anti‑stress, and anti‑cancer effects.
Abstract
Female SHR mice received 5-days long monthly courses of delta-sleep inducing peptide (DSIP) preparation "Deltaran" subcutaneously in dose 5 mkg/kg during all their lives. It was demonstrated, that last 10% (most aged) of mice which received Deltaran lived for 16% longer than the controls. They had significantly higher amount of vertical activity in the "open field" test, than the controls, starting from time when they were 6 months old and until their natural death. Mice of Deltaran group spent 73% more time in the open arms of elevated plus maze, and 9 times more often explored the extremities of this maze, than controls. Also Deltaran slowed the spontaneous carcinogenesis parameters. It's assumed that DSIP preparation "Deltaran" have geroprotective, anxiolytic and antitumor activity.
Study Information
pubmed
2009