[Rat tissues antioxidant status correction by peptide delta sleep during physiological aging of the organism].
Bondarenko. T I TI; Kutilin. D S DS; Mikhaleva. I I II
Key Findings
- Sub‑cutaneous DSIP (100 mg/kg) increased glutathione antioxidant levels in rat tissues.
- The increase was observed across different ages (2‑24 months) indicating a broad effect during aging.
- Non‑renewable, post‑mitotic tissues (e.g., brain, heart) showed the strongest antioxidant response.
Practical Outcomes
- The results suggest DSIP might have antioxidant‑enhancing properties, but the dose used in rats is far higher than any human‑safe amount and no human data exist. For now, biohackers should treat this as an early‑stage finding that needs more research before it can be turned into a real‑world protocol.
Summary
A study in rats found that giving them a peptide called delta‑sleep inducing peptide (DSIP) raised the levels of the antioxidant glutathione in many tissues, especially in long‑lived cells like brain and heart. The boost was seen at various ages and was achieved by injecting a very high dose (100 mg per kg body weight) for five days each month.
Abstract
It is shown that exogenous delta-sleep inducing peptide increases glutathione antioxidant system level in rat tissues at different stages of ontogenesis, by subcutaneous injection to rats 2-24 months postnatal development in a dose of 100 mg/kg animal body weight by courses of 5 consecutive days per month, and this effect is especially marked in non-renewable postmitotic tissues.
Study Information
pubmed
2014