[Effect of deltaran and melatonin on immune system in rats with experimental contact dermatitis].
Shandra. O O OO
Key Findings
- Chrome‑induced contact dermatitis in rats severely disrupted both humoral (antibody‑based) and cell‑mediated immunity and reduced neutrophil stability.
- Melatonin and deltaran each partially restored immune function when given separately.
- Combined administration of melatonin and deltaran produced a stronger, almost exponential, improvement in immune parameters.
Practical Outcomes
- The study suggests that melatonin might boost immune health, especially when paired with other agents, but deltaran is not a known supplement for humans. Because the research is in rats with a specific skin‑irritation model, there’s no clear protocol to apply to human longevity or performance. Biohackers should treat this as an early‑stage finding that needs human trials before any real‑world use.
Summary
In a rat study, skin inflammation caused by chromium messed up the animals' immune system and made their white blood cells less stable. Giving the rats melatonin, a supplement many people already use, and a compound called deltaran—either alone or together—helped fix those immune problems, with the combo working best.
Abstract
The aim of the work was investigation of both humoral and cell-mediated immunity together with leukocytes functional stability indexes in rats with the experimental contact dermatitis (ECD) in conditions of complex pharmacological correction using deltaran and melatonin. Experimental trials were performed under conditions of chronic experiment on model chrome-induced ECD. Both deltaran and melatonin either alone or in combination were used for complex pharmacological correction of humoral and cell-mediated immunity and also for stability of leukocytes. The data obtained showed the expressed disturbances of humoral and cell-mediated immunity and neutrophils' functional stability damage under conditions of chrome-induced ECD in rats. The revealed alterations in functional activity of the immune system were successfully corrected using the combined administration of deltaran and melatonin. The activity of medical complex had exponential character.
Study Information
pubmed
2014