Epitalon

Epithalon, Epithalone, Epithalamin, Epithalamine, AEDG

A synthetic tetrapeptide that activates telomerase, lengthens telomeres, and promotes anti-aging effects by modulating pineal gland functions and melatonin production.

Molecular Profile

Formula C₁₄H₂₂N₄O₉

Mol. Weight 390.35 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 5-10 mg/day	5-10 mg/day	High (95%)	SUB
Intranasal 10-20 mg/day	10-20 mg/day	Moderate (60%)	INT
Oral 3-6 mg/day	3-6 mg/day	Low (20%)	ORA

How It Works

How It Works: Epitalon primarily functions as a telomerase activator, helping to maintain telomere length and delay cellular aging, while also influencing pineal gland activity for broader anti-aging effects.

Telomerase Activation: Stimulates telomerase enzyme to elongate telomeres, extending cellular lifespan and reducing senescence.
Melatonin Regulation: Enhances melatonin synthesis in the pineal gland, improving circadian rhythms, sleep quality, and antioxidant protection.
Antioxidant Properties: Reduces oxidative stress and free radical damage in tissues, supporting overall cellular health.
Immune Modulation: Promotes lymphocyte proliferation and interferon production, enhancing immune function.
Gene Expression: Influences epigenetic mechanisms to regulate gene activity related to aging and repair.

Pairs Well With

Latest Studies

See All Studies

Utility 3

pubmed Sep 4, 2025

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.

Al-Dulaimi. Sarah S; Thomas. Ross R; Matta. Sheila S; Roberts. Terry T

The study shows that the peptide epitalon can lengthen telomeres in human cells in a lab dish. In normal cells it does this by boosting the telomerase enzyme, while in cancer cells it also triggers an alternative telomere‑lengthening pathway. These results support the idea that epitalon might help maintain telomere length, a marker linked to aging, but the work was done in cell cultures, not in people.

Utility 2

pubmed Jan 7, 2025

Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.

Ullah. Safeer S; Haider. Zaheer Z; Perera. Chalani Dilshani CD; Lee. Su Hyeon SH...

The study showed that adding the peptide Epitalon to cow egg cells in the lab boosted the activity of telomerase, which helped more eggs mature and led to better-quality embryos after freezing. While the results are promising for improving egg health, they were done in animals and in a very controlled lab setting, so it’s not clear how it would work in humans or everyday use.

Utility 2

pubmed 2008

[Biological activity of regulatory peptides in model experiments in vitro].

Kozina. L S LS; Arutiunian. A V AV; Stvolinskiĭ. S L SL; Khavinson. V Kh V...

In lab tests, epitalon and similar tiny proteins didn’t act like classic antioxidants, but they could change the shape of human lipoproteins enough to slow down fat oxidation. They also made red blood cell membranes tougher against bursting and raised the level of reactive oxygen inside cells while generally lowering the number of dead nerve cells (except for epitalon). The authors think these peptides might help control cell death processes in a living body.

Browse All Studies