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Epithalon, Epithalone, Epithalamin, Epithalamine, AEDG
A synthetic tetrapeptide that activates telomerase, lengthens telomeres, and promotes anti-aging effects by modulating pineal gland functions and melatonin production.
Khavinson. Vladimir V; Shataeva. Larisa L; Chernova. Anna A
The study proposes that the peptide epitalon can directly bind to a specific DNA sequence (ATTTTC) in the promoter region of the telomerase gene, acting like a tiny transcription factor. This binding might help turn on telomerase, which is linked to cell longevity, and could explain why regulatory peptides are reported to boost lifespan in lab experiments.
Lin'kova. N S NS; Poliakova. V O VO; Trofimov. A V AV; Sevost'ianova. N N NN; Kvetnoĭ. I M IM
The review says that peptides from the pineal gland, especially epithalamin and epitalon, help keep the thymus (an immune organ) healthier as we age, more so than thymus‑derived peptides do for the pineal gland. The benefit seems to come from these pineal peptides turning on certain genes that support immune‑endocrine balance.
Zamorskiĭ. I I II; Shchudrova. T S TS
In a lab study, the pineal peptide epitalon (along with two kidney‑specific tripeptides) helped protect kidneys from damage caused by severe muscle breakdown. It reduced cell toxicity, oxidative stress, and energy problems in the kidney, leading to better kidney function and less acute failure in the animal model.
Al-Dulaimi. Sarah S; Thomas. Ross R; Matta. Sheila S; Roberts. Terry T
The study shows that the peptide epitalon can lengthen telomeres in human cells in a lab dish. In normal cells it does this by boosting the telomerase enzyme, while in cancer cells it also triggers an alternative telomere‑lengthening pathway. These results support the idea that epitalon might help maintain telomere length, a marker linked to aging, but the work was done in cell cultures, not in people.
Ullah. Safeer S; Haider. Zaheer Z; Perera. Chalani Dilshani CD; Lee. Su Hyeon SH; Idrees. Muhammad M...
The study showed that adding the peptide Epitalon to cow egg cells in the lab boosted the activity of telomerase, which helped more eggs mature and led to better-quality embryos after freezing. While the results are promising for improving egg health, they were done in animals and in a very controlled lab setting, so it’s not clear how it would work in humans or everyday use.
Kozina. L S LS; Arutiunian. A V AV; Stvolinskiĭ. S L SL; Khavinson. V Kh VKh
In lab tests, epitalon and similar tiny proteins didn’t act like classic antioxidants, but they could change the shape of human lipoproteins enough to slow down fat oxidation. They also made red blood cell membranes tougher against bursting and raised the level of reactive oxygen inside cells while generally lowering the number of dead nerve cells (except for epitalon). The authors think these peptides might help control cell death processes in a living body.
Ivko. O M OM; Drobintseva. A O AO; Leont'eva. D O DO; Kvetnoy. I M IM; Polyakova. V O VO; Linkova. N...
A lab study on human pineal and thymus cells found that the peptide epitalon (called AEDG) can boost markers of mitochondrial health and lower a ribosomal protein that rises when cells age, suggesting it may help keep these cells healthier in a dish.
Kozina. L S LS
The study found that a few short peptides, including epitalon, can help protect cells from low‑oxygen stress in animal experiments. Pinealon worked best, while epitalon showed a modest protective effect. The benefit seems to come from boosting the body's own antioxidant enzymes rather than just blocking harmful oxygen‑free radicals.