[Influence of peptides from pineal gland on thymus function at aging].
Lin'kova. N S NS; Poliakova. V O VO; Trofimov. A V AV; Sevost'ianova. N N NN; Kvetnoĭ. I M IM
Key Findings
- Pineal peptides (epithalamin, epitalon) show stronger anti‑aging effects on the thymus than thymic peptides do on the pineal gland.
- Epitalon appears to slow or reverse thymus involution, which is linked to better immune function in older age.
- The proposed mechanism involves activation of transcription of proteins that mediate immuno‑endocrine cooperation.
Practical Outcomes
- For biohackers interested in immune aging, epitalon may be worth exploring as a supplement to support thymus health, but the abstract provides no dosing or safety details. Treat it as an experimental option and look for human trials before making it a core part of a longevity protocol.
Summary
The review says that peptides from the pineal gland, especially epithalamin and epitalon, help keep the thymus (an immune organ) healthier as we age, more so than thymus‑derived peptides do for the pineal gland. The benefit seems to come from these pineal peptides turning on certain genes that support immune‑endocrine balance.
Abstract
The interference between thymus and pineal gland during their involution is considered in this review. The research data about influence of thymus peptides on pineal gland and pineal peptides on thymus is summarized. Analysis of these data showed that pineal peptides (epithalamin, epitalon) had more effective geroprotective effect on thymus involution in comparison with geroprotective effect of thymic peptides (thymalin, thymogen) on involution of pineal gland. The key mechanisms of pineal peptides effect on thymus dystrophy is immunoendocrine cooperation, which is realized as transcription's activation of various proteins.
Study Information
pubmed
2010