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FGL-S

FGLs, truncated FGL, NCAM peptide mimetic

Truncated dimeric NCAM-derived peptide mimetic with antidepressant effects and neuroplasticity promotion via FGFR activation.

Molecular Profile
Formula C47H82N18O18
Mol. Weight 1187.3 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
10 mg/kg
SUB
Intranasal
25-200 mg
INT

How It Works

How It Works: FGL-S is a truncated dimer of FGL L that binds to FGF receptors, promoting neuroplasticity and modulating emotionality through central nervous system effects.

  • Enhances phosphorylation of FGFR1 in a dose-dependent manner
  • Improves spatial memory in NCAM knockout models
  • Rapid antidepressant effects are AMPA receptor-dependent, blocked by NBQX
  • Facilitates synaptic plasticity, synaptogenesis, and neuronal survival.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Studies

Utility 3
pubmed Apr 9, 2018

Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates.

Turner. Cortney A CA; Lyons. David M DM; Buckmaster. Christine L CL; Aurbach. El...

A short piece of the NCAM protein called FGL‑S can get into the brain after being given outside the head and, in rats, it lifts signs of depression without changing anxiety. The brain levels match blood levels in both rats and monkeys, suggesting it can cross the blood‑brain barrier. The antidepressant effect depends on AMPA‑type glutamate receptors.

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