Neural cell adhesion molecule peptide mimetics modulate emotionality: pharmacokinetic and behavioral studies in rats and non-human primates.
Turner. Cortney A CA; Lyons. David M DM; Buckmaster. Christine L CL; Aurbach. Elyse L EL; Watson. St...
A short piece of the NCAM protein called FGL‑S can get into the brain after being given outside the head and, in rats, it lifts signs of depression without changing anxiety. The brain levels match blood levels in both rats and monkeys, suggesting it can cross the blood‑brain barrier. The antidepressant effect depends on AMPA‑type glutamate receptors.