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Follistatin 315

Activin-Binding Protein, FSH-Suppressing Protein, FST-315, FS-315

Quick Stats
Studies 14
Trials 93
Not Yet Recruiting NA INTERVENTIONAL NCT06220240

Energy Deficiency and Athletic Performance

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Energy availability (EA) refers to the balance between daily energy intake and exercise energy expenditure. Athletically inadequate EA is defined as low energy availability (LEA). Energy deficits occur throughout life, from young athletes with a relative lack of energy in sports or the female athlete triad to older adults struggling with weight loss. Acute and/or chronic LEA can cause negative athletic and health outcomes in athletes. It is known that LEA, as an energy saving mechanism, suppresses the reproductive system and causes disruption of the menstrual cycle, as well as causing many interrelated endocrine-related physiological consequences by changing other hormonal pathways. Menstrual dysfunction due to LEA causes various risks as it can disrupt the EC during training and competition. Therefore, low EA may contribute to poor sports performance due to detrimental endocrine effects. Various parameters such as body mass and nutritional intake affect the performance of athletes, and LEA is frequently reported among athletes with intense training programs. LEA combined with high training volumes; It can cause negative consequences such as impaired protein synthesis/degradation rate, impaired hormonal and training response, increased risk of fatigue, and these can lead to decreased performance. Resting metabolic rate, which indicates the energy expended for basic body functions, is considered a potential objective indicator of energy availability. Regulation of dietary energy intake in the management of LEA in athletes covers a wide area in the literature. However, LEA is caused not only by a deficiency in energy intake but also by an excess in energy expenditure. In the light of this information, the aim of the study is to examine the acute period effects of the training program in which exercise energy expenditure is reduced in terms of energy availability and athletic performance.

Detailed Description

Voluntary participants who have been diagnosed with energy deficiency will be included in the study. Signed voluntary consent will be obtained from participants. Participants will be divided into two groups. Study groups will be as follows: a) Modified Training, b) Routine Training.

Interventions

Name: Modified Training Programme
Type: OTHER
Description: Eccentric muscle contractions and 3-minute rest breaks will be used.
Name: Routine Training Programme
Type: OTHER
Description: A routine training program will be used.

Primary Outcomes

Measure: Energy Availability
TimeFrame: change from baseline pain at 2 weeks
Description: The underlying etiology of Relative Energy Deficiency in Sports is low energy availability, which occurs when dietary energy intake is inadequate for an athlete's physical activity level. "Energy availability = Energy Intake (kcal) - Exercise Energy Expenditure (kcal/fat - free mass \[fat free mass; kg\])"
Measure: Relative Energy Deficiency in Sports Clinical Assessment Tool (RED-S CAT)
TimeFrame: 3 times for 2 weeks
Description: It is a clinical assessment tool used to evaluate athletes or active individuals with suspected low energy availability and serves as a guide for clinicians and coaches in return-to-play decisions.
Measure: Running Performance Analysis - Biomechanics
TimeFrame: 3 times for 2 weeks
Description: Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the biomechanics.
Measure: Running Performance Analysis - Running Speed
TimeFrame: 3 times for 2 weeks
Description: Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the running speed.
Measure: Running Performance Analysis - Economy of the Running
TimeFrame: 3 times for 2 weeks
Description: Performance analysis will be performed on a 10-meter platform with DigitSole in order to evaluate the economy of the athlete's running activity.

Trial Information

NCT ID

NCT06220240

Status

Not Yet Recruiting

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Istanbul University - Cerrahpasa

Last Updated

December 15, 2025