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GHK-Cu

Copper Tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper, Prezatide Copper

Quick Stats
Studies 149
Trials 1
Score 3
2018 pubmed 94 citations

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.

Pickart. Loren L; Margolina. Anna A

Key Findings

  • Stimulates blood‑vessel and nerve growth and increases collagen, elastin, and glycosaminoglycan production.
  • Shows protective actions such as anti‑inflammatory, anti‑cancer, DNA repair, and suppression of NF‑κB (a driver of aging).
  • Improves repair in multiple tissues—including skin, lung, bone, liver, and stomach lining—suggesting broad regenerative potential.

Practical Outcomes

  • For biohackers, GHK‑Cu could be explored as a supplement or topical agent to support skin health, joint and connective‑tissue repair, and overall anti‑aging strategies. While the review highlights many benefits, it does not provide specific dosing guidelines, so start with low, well‑studied doses and monitor for any side effects.

Summary

GHK‑Cu is a tiny peptide that appears to boost tissue repair and protect cells. It helps grow new blood vessels and nerves, ramps up collagen and other skin‑supporting proteins, and has anti‑inflammatory, anti‑cancer, DNA‑repair, and stress‑reducing effects. Recent gene‑level data suggest it works through many pathways that are linked to aging and disease.

Abstract

The human peptide GHK (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.

Study Information

Provider

pubmed

Year

2018

Date

2018-07-07T00:00:00.000Z

DOI

10.3390/ijms19071987

Citations

94

References

65