Multi working mode SPR chip laboratory for high refractive index detection.
Ren. Zhuo Z; Liu. Chunlan C; Wei. Yong Y; Liu. Chunbiao C; Shi. Chen C; Wang. Xingkai X; Tang. Yixiong Y; Wang. Rui R; Liu. Zhihai Z
Key Findings
- A multi‑mode SPR chip can detect GHK‑Cu with a sensitivity of 9.729 nm per mg/mL.
- The chip operates in a high refractive index range of 1.571‑1.595, allowing detection of various analytes.
- The device can simultaneously detect glucose and GHK‑Cu, offering dual‑parameter measurement.
Practical Outcomes
- The sensor could be useful for labs or hobbyists who want to measure GHK‑Cu concentrations in fluids, but it doesn’t provide actionable guidance on dosing, safety, or performance benefits for users.
Summary
This paper describes a new optical sensor chip that can measure the amount of GHK‑Cu (a copper‑binding peptide) in liquid samples, but it doesn’t give any information about how the peptide works in the body, how much to take, or what benefits it provides. It’s mostly a technical method for detecting the peptide, not a guide for using it.
Abstract
The Fiber SPR chip laboratory has become a popular choice in biochemical detection. To meet the needs of different kinds of analytes for the detection range and number of channels of the chip, we proposed a multi-mode SPR chip laboratory based on microstructure fiber in this paper. The chip laboratory was integrated with microfluidic devices made from PDMS and detection units made of bias three-core fiber and dumbbell fiber. By injecting light into different cores of a bias three-core fiber, different detection areas of dumbbell fiber can be selected, enabling the chip laboratory to enter high refractive index detection, multi-channel detection and other working modes. In the high refractive index detection mode, the chip can detect liquid samples with a refractive index range of 1.571-1.595. In multi-channel detection mode, the chip can achieve dual parameter detection of glucose and GHK-Cu, with sensitivities of 4.16 nm/(mg/mL) and 9.729 nm/(mg/mL), respectively. Additionally, the chip can switch to temperature compensation mode. The proposed multi working mode SPR chip laboratory, based on micro structured fiber, offers a new approach for the development of portable testing equipment that can detect multiple analytes and meet multiple requirements.
Study Information
pubmed
2023
2023-06-19T00:00:00.000Z
10.1364/oe.493337