Effects of Tripeptide Gly-His-Lys in Pain-Induced Aggressive-Defensive Behavior in Rats.
Sever'yanova. L А LА; Dolgintsev. M E ME
Key Findings
- Intraperitoneal GHK (5‑150 µg/kg) lowered pain‑induced aggressive‑defensive behavior in rats.
- The effect was observed across a range of doses, indicating dose‑dependence.
- Administering L‑lysine alone at amounts matching its content in GHK produced similar effects, highlighting lysine as the key active component.
Practical Outcomes
- For the biohacker community, this research suggests GHK (or its lysine component) might have analgesic or stress‑modulating properties, but the study used injectable doses in rats, not oral supplements for humans. More research is needed before any real‑world dosing protocol can be recommended.
Summary
A study in rats found that injecting the tripeptide Gly‑His‑Lys (GHK) reduced aggressive behavior triggered by pain. The calming effect appears to come mainly from the lysine part of the molecule.
Abstract
We studied the effect of Gly-His -Lys tripeptide administered intraperitoneally in doses of 5, 15, 50 and 150 μg/kg on pain-induced aggressive-defensive behavior. A foot-shock model of aggression in rats grouped in pairs in an electrified chamber was used. Analgesic and antiaggresiogenic effects of the peptide were demonstrated. It was found the L-lysine residue plays the key role in these effects, because they were observed under the influence of L-lysine administration in doses close to its equimolar content in the studied tripeptide.
Study Information
pubmed
2017
2017-11-27T00:00:00.000Z
10.1007/s10517-017-3943-3