Score
2
2002
pubmed
Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor.
Smakhtin. M Yu MY; Sever'yanova. L A LA; Konoplya. A I AI; Shveinov. I A IA
Key Findings
- Repeated intraperitoneal injections of GHK increased mitotic activity of hepatocytes.
- GHK suppressed immune reactivity in a dose‑dependent manner, reducing antibody‑producing cells and delayed‑type hypersensitivity.
- These effects were observed across a broad dose range (1.5–450 mg/kg).
Practical Outcomes
- GHK may have liver‑regenerative and immunosuppressive properties, but the evidence is limited to high‑dose animal injections. For biohackers, the study does not provide a safe, actionable protocol for humans; further human research is needed before considering GHK for liver health or immune modulation.
Summary
In an animal study, giving the tripeptide Gly‑His‑Lys (GHK) by injection several times boosted liver cell division and simultaneously lowered immune activity, but the work was done in rodents with high doses and a route (intraperitoneal injection) that isn’t practical for people.
Abstract
Ten intraperitoneal injections of tripeptide Gly-His-Lys in doses of 1.5, 5, 50, 150, and 450 mg/kg stimulated mitotic activity of hepatocytes and dose-dependently suppressed immune reactivity (number of antibody-producing cells and delayed-type hypersensitivity reaction).
Study Information
Provider
pubmed
Year
2002
DOI
10.1023/a:1020242127443