Scientists made a special coating for titanium implants that slowly releases copper ions when the surrounding pH changes. The coating contains tiny silica particles loaded with the GHK‑Cu peptide, and it can both kill bacteria and be friendly to bone cells. This work is mainly about improving medical implants, not about taking the peptide as a supplement.

Despite the fact that titanium has been widely applied in the replacement of bone defects, prosthesis failure still occurred because of the lack of adequate bone-bonding ability and the incidence of post-surgery infections. Concentration-dependent effects of therapeutic copper ions (Cu²⁺) for antibacterial and osteogenic activity have been well-established in the field of biomedical application. In this study, we prepared mesoporous silica nanoparticles (MSN) and MSN-COOH with uniform sphere size (~100 nm) and developed multifunctional chitosan coatings loaded with MSN@GHK-Cu (glycyl-L-histidyl-l-lysine-Cu²⁺) as a suitable strategy by electrophoretic deposition (EPD). The microstructure and composition of the coating were comprehensively characterized by using SEM, XRD, FTIR, and TEM, respectively. The functional activity of Cu²⁺ releasing from the surface was dependent on the pH value of the titanium surface. Through the controllable release of Cu²⁺, the coating achieved not only inhibited adhesion of bacteria but also had good cytocompatibility. The coating based on EPD technique could be considered as a promising surface modification approach for the controlled delivery in situ of drug or other biomolecules.