NMR studies on binary and ternary Pd(II) complexes formed by the growth-modulating tripeptide glycylhistidyllysine and nucleotides.
Laussac. J P JP; Pasdeloup. M M; Hadjiliadis. N N
Key Findings
- Glycyl‑histidyl‑lysine can form stable binary complexes with Pd(II) in acidic conditions.
- When combined with nucleotides (IMP or GMP), ternary Pd(II) complexes also form and are structurally characterized by NMR.
- The research identifies which atoms in the peptide and nucleotides coordinate the palladium ion.
Practical Outcomes
- For the biohacker community, this paper offers no direct guidance on dosing, supplementation, or health protocols. It is a technical description of metal‑peptide chemistry that does not translate into actionable longevity or performance strategies.
Summary
The study looks at how a small blood peptide (glycyl‑histidyl‑lysine) and some nucleotides bind to palladium ions, using NMR spectroscopy to figure out the structures of these complexes. It’s a basic chemistry investigation and doesn’t test any health effects or practical uses.
Abstract
The mechanism of transport of Pt(II) and Pd(II) into tissues through blood and that of their elimination in kidney is incompletely known so far. In this respect, the binding of palladium by the tripeptide glycyl-L-histidyl-L-lysine (GHL), a constituent of the human plasma, as a binary complex, and by the nucleotides 5'-IMP and 5'-GMP, as ternary complexes, has been studied by 1H and 13C NMR spectroscopy. These studies have been conducted in aqueous media and at different ligand/metal ratios. At acidic pH, resonances were observed for binary and ternary kinetically stable complexes, and binding sites in these complexes were identified by the effect of binding on chemical shifts of protons and carbon resonances. From these data, stoichiometries and structures of these complexes were proposed.
Study Information
pubmed
1987
1987-07-01T00:00:00.000Z
10.1016/0162-0134(87)80066-1
15
21