Effects of Gly-His-Lys-D-Ala Peptide on Skin Wound Regeneration Processes.
Rakhmetova. K K KK; Mishina. E S ES; Bobyntsev. I I II; Bezhin. A I AI; Vorvul. A O AO
Key Findings
- Daily intracutaneous injection (0.5 µg/kg) increased fibroblast numbers in the wound.
- The peptide raised macrophage counts while lowering granulocyte (neutrophil) numbers, indicating reduced inflammation.
- Wounds showed stronger contraction and faster overall healing by day 30.
Practical Outcomes
- The results hint that this peptide could be useful for speeding skin repair, but the study was done only in rats and used direct injections, not a format people can easily use. More human research is needed before recommending it for personal wound‑care protocols, and safe dosing for people remains unknown.
Summary
In a rat study, injecting a tiny amount of the Gly‑His‑Lys‑D‑Ala peptide around a skin wound helped the healing process. It boosted cells that build new tissue, reduced inflammatory cells, and led to faster wound closure by day 30.
Abstract
We evaluated the effects of the Gly-His-Lys-D-Ala peptide in a dose 0.5 μg/kg on skin wound regeneration in male Wistar rats (n=80) after initial surgical debridement when administered intracutaneously around the site of injury. Histological (severity of the inflammatory reaction, formation of granulation tissue, and epithelialization terms) and morphometric (number of fibroblastic cells, macrophages, granulocytes, and lymphocytes) studies were performed on autopsy specimens on days 3, 7, 10, and 30 of the experiment. Daily intracutaneous injection of the peptide resulted in an increase in the number of fibroblastic cells and macrophages, as well as in a decrease in the number of granulocytes against the background of active wound contraction on day 30 of the experiment. Thus, Gly-His-Lys-D-Ala alleviated the inflammatory reaction and promoted the regenerative processes.
Study Information
pubmed
2024
2024-02-12T00:00:00.000Z
10.1007/s10517-024-06035-w
2
16