[Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane].
Smakhtin. M Iu MIu; Konoplia. A I AI; Sever'ianova. L A LA; Shveĭnov. I A IA
Key Findings
- Low dose (â1.5âŻÂ”g/kg) improved liver cell function and immune response in toxinâdamaged livers
- Higher doses (2.5â150âŻÂ”g/kg) increased liver cell division but also caused immunosuppression
- The highest dose (150âŻÂ”g/kg) worsened blood chemistry and liver tissue damage
Practical Outcomes
- For biohackers, the study suggests that tiny amounts of GHKâCu might support liver repair, but larger amounts could be harmful. Because the work was done in animals using injections, it isnât a readyâtoâuse protocol for humans, and any dosing should be approached with caution and more research.
Summary
In a shortâterm animal study, giving the peptide GHKâCu by injection helped liver cells grow and work better at a very low dose, but a much higher dose actually suppressed the immune system and made liver damage worse. The results show that the effect depends heavily on how much is used.
Abstract
10-day intraperitoneal administration of the tripeptie Gly-His-Lys in doses 2.5 and 150 mu/kg raises of mitotic index of hepatocytes in acute toxic damage to the liver. In the dose 1.5 mu/kg this peptie corrects both functional activity of hepatocytes and immunological responsiveness. In a dose of 150 mu/kg the peptie has a more potent immunosuppressive action and deteriorates biochemical indices of blood serum as well as dystrophic changes in the liver.
Study Information
pubmed
2003