GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
N-aminoimidazolidin-2-one peptidomimetics.
Doan. Ngoc-Duc ND; Hopewell. Robert R; Lubell. William D WD
Key Findings
- A new Aid scaffold was synthesized by alkylating a semicarbazone with ethylene bromide.
- The Aid scaffold rigidifies the peptide backbone, acting like an aza‑Freidinger‑Veber lactam.
- Twenty‑five Aid‑based peptides were produced, among them eight analogues of GHRP‑6.
Practical Outcomes
- For biohackers, this study offers no direct guidance on dosing, safety, or performance benefits. It is mainly a chemistry method that could be useful for future drug design, but it does not provide actionable protocols for current use.
Summary
Scientists created a new chemical building block (Aid) that makes peptide chains stiffer and reported how they made 25 different versions, including eight that look like the peptide GHRP‑6. The paper focuses on the chemistry of making these molecules, not on how they work in the body or how to use them.
Abstract
The synthesis of N-aminoimidazolidin-2-one (Aid) peptidomimetics has been achieved by alkylation of the urea nitrogen of a semicarbazone residue using ethylene bromide. The Aid scaffold combines electronic and structural constraints to rigidify the peptide backbone in the equivalent of an aza variant of a Freidinger-Veber lactam. The syntheses and isolation of 25 Aid peptides, including eight GHRP-6 analogues, are reported to demonstrate the utility of this method for controlling conformation.
Study Information
pubmed
2014
2014-04-04T00:00:00.000Z
10.1021/ol500739k
17
35