GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics.
Zhang. Jinqiang J; Proulx. Caroline C; Tomberg. Anna A; Lubell. William D WD
Key Findings
- A copper‑catalyzed A(3)-coupling method can link secondary amines to aza‑propargylglycine residues in peptides.
- Using GHRP‑6 as a test case, 18 new aza‑lysine peptide analogs were successfully synthesized.
- These constrained peptide mimics could be useful for studying lysine‑related interactions and post‑translational modifications in future research.
Practical Outcomes
- At present, the study offers no direct guidance for dosing, safety, or performance enhancement with GHRP‑6. It is a laboratory‑focused technique that may eventually enable the creation of new peptide drugs, but there are no actionable protocols for biohackers or self‑experimenters right now.
Summary
Scientists developed a new chemistry trick to attach special building blocks to a peptide called GHRP‑6, creating 18 slightly different versions. The work is about how to make these modified peptides in the lab, not about how they work in the body or how to use them for health.
Abstract
Copper catalyzed coupling of Mannich reagents to aza-propargylglycine residues has been employed to synthesize constrained aza-lysine peptides. Employing growth hormone releasing peptide-6 (GHRP-6) as a model peptide and a variety of secondary amines, 18 aza-Lys analogs were synthesized by this so-called A(3)-coupling reaction. This effective method for making constrained aza-Lys-peptides offers strong potential for exploring various recognition events implicating lysine residues including post-translational peptide modification.
Study Information
pubmed
2013
2013-12-13T00:00:00.000Z
10.1021/ol403297v
28
41