GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Diversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine.
Traoré. Mariam M; Doan. Ngoc-Duc ND; Lubell. William D WD
Key Findings
- A new synthesis route for azapeptides with basic residues using hydrazone‑protected aza‑glycine.
- Successful creation of 29 different azapeptide examples, including a library of GHRP‑6 analogs.
- Demonstrated both solution‑phase and solid‑phase techniques for building these modified peptides.
Practical Outcomes
- The paper provides a chemistry method, not a ready‑to‑use protocol for health or performance. Biohackers would need additional research to see if these new GHRP‑6 analogs are safe, effective, or better than existing versions.
Summary
Scientists developed a new chemical recipe to make special versions of peptides that contain altered basic amino acids (like lysine, ornithine, and arginine). They used this method to create a collection of modified Growth Hormone Releasing Peptide‑6 (GHRP‑6) analogs, but the study only describes how to make them, not how they work in the body.
Abstract
Aza-peptides with basic amino acid residues (lysine, ornithine, arginine) and derivatives were synthesized by an effective approach featuring alkylation of a hydrazone-protected aza-glycine residue with α-bromo ω-chloro propane and butane to provide the corresponding alkyl chloride side chains. Displacement of the chloride with azide and various amines gave entry to azaOrn, azaLys, and azaArg containing peptides as demonstrated by the solution and solid-phase syntheses of 29 examples, including an aza-library of Growth Hormone Releasing Peptide-6 analogs.
Study Information
pubmed
2014
2014-06-24T00:00:00.000Z
10.1021/ol501586y
20
29