Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

GHRP-6

Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

Quick Stats
Studies 702
Trials 0
Score 1
2007 pubmed

Transient hypogonadotropic hypogonadism in an amateur kickboxer after head trauma.

Tanriverdi. F F; Unluhizarci. K K; Selcuklu. A A; Casanueva. F F FF; Kelestimur. F F

Key Findings

  • Acute head trauma from kickboxing can cause short‑term hypogonadotropic hypogonadism (low testosterone due to pituitary suppression).
  • A combined GHRH + GHRP‑6 stimulation test showed that the growth‑hormone axis remained intact despite the injury.
  • Hormone abnormalities and related symptoms resolved spontaneously within 3‑9 months.

Practical Outcomes

  • If you do high‑impact combat sports, be aware that a concussion can temporarily mess up your sex hormones. Monitoring testosterone, prolactin, and possibly using a GHRH + GHRP‑6 test can help assess pituitary function after injury. Most cases appear to recover on their own, so routine screening after a concussion is advisable, but no specific GHRP‑6 dosing protocol is suggested.

Summary

A 20‑year‑old amateur kickboxer got a head injury during a bout and later felt less interested in sex and had trouble getting an erection. Blood tests showed low testosterone and a bit high prolactin, but his growth‑hormone response to a GHRH + GHRP‑6 stimulation test was normal. Within a few months his hormone levels and symptoms went back to normal, showing the problem was temporary.

Abstract

Traumatic brain injury (TBI) is a frequent health problem and increased prevalence of neurendocrine dysfunction in patients with TBI has been reported. Sports injuries and particularly boxing may result in pituitary dysfunction. However, transient hypogonadotropic hypogonadism after an acute head trauma due to boxing and/or kickboxing has not been defined yet. We describe the case of a 20-yr-old male amateur kickboxer who was admitted to hospital complaining of decreased libido and impotence 2 weeks after an intensive bout. Basal hormone levels were compatible with mild hyperprolactinemia and hypogonadotpopic hypogonadism. GH axis was evaluated by GHRH+GHRP-6 test and peak GH level was within normal reference range. Three months later his complaints improved and abnormalities in basal hormone levels normalized. He was also re-evaluated 9 months after the first evaluation; basal hormone levels were within normal ranges and he had no complaints. In conclusion acute head trauma due to kickboxing may cause transient gonadotropin deficiency. Therefore, screening the pituitary functions of sportsmen dealing with combative sports is crucial.

Study Information

Provider

pubmed

Year

2007

DOI

10.1007/bf03347414