GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Solid phase synthesis of a GHRP analog containing C-terminal thioamide group.
Majer. Z Z; Zewdu. M M; Hollósi. M M; Sepródi. J J; Vadász. Z Z; Teplán. I I
Key Findings
- Error
Practical Outcomes
- Error
Summary
Error: Timeout.
Abstract
[Lyst6]GHRP, the C-terminally thionated analog of the highly potent growth hormone releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 was prepared by using solid support. The success of the synthesis showed that Lawesson's reagent can be used for selective thionation of an amide group not only in solution but also on the surface of a resin. The C-terminal thioamide group proved to be stable under the conditions of the solid phase synthesis.
Study Information
pubmed
1988
1988-02-15T00:00:00.000Z
10.1016/0006-291x(88)90730-9