GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
A novel 3-substituted benzazepinone growth hormone secretagogue (L-692,429).
Schoen. W R WR; Pisano. J M JM; Prendergast. K K; Wyvratt. M J MJ; Fisher. M H MH; Cheng. K K; Chan. W W WW; Butler. B B; Smith. R G RG; Ball. R G RG
Key Findings
- L-692,429 is a non‑peptide compound that stimulates growth hormone release, acting as a GHRP‑6 mimic.
- The seven‑membered benzazepinone core (vs. six‑ or eight‑membered lactams) provides the strongest activity.
- Molecular modeling indicates structural similarity in how L-692,429 and GHRP‑6 interact with the GH‑secretagogue receptor.
Practical Outcomes
- At this stage the molecule is only a laboratory prototype; it isn’t available for human use and no dosing or safety data exist. For biohackers, the main takeaway is that future oral or non‑peptide GH secretagogues may become viable, so watching further development of this class could be worthwhile.
Summary
Scientists made a new small molecule called L-692,429 that mimics the GH‑releasing peptide GHRP‑6 and can trigger the body to release growth hormone. The study shows that a seven‑membered benzazepinone ring works better than similar six‑ or eight‑membered structures, and computer models suggest it fits the same receptor pocket as the peptide.
Abstract
The 3-substituted benzazepinone, L-692,429 (compound 1), is the prototype compound of a novel class of compounds that stimulate release of growth hormone (GH). The molecule evolved from efforts to identify a non-peptide mimic of the growth hormone-releasing hexapeptide, GHRP-6. Compound 1 is prepared by sequential attachment of dimethyl-beta-alanine and 2'-biphenylyltetrazole side chains to a chiral 3-aminobenzolactam nucleus. Comparison of the biological activity of 1 with the corresponding six- and eight-membered lactam analogs shows the seven-membered benzazepinone skeleton to be preferred. Molecular modeling of the structurally diverse GH secretagogues, L-692,429 and GHRP-6, was performed.
Study Information
pubmed
1994
1994-04-01T00:00:00.000Z
10.1021/jm00033a006