GHRP-6
Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
A nonpeptidyl growth hormone secretagogue.
Smith. R G RG; Cheng. K K; Schoen. W R WR; Pong. S S SS; Hickey. G G; Jacks. T T; Butler. B B; Chan. W W WW; Chaung. L Y LY; Judith. F F
Key Findings
- L‑692,429 is a non‑peptidyl compound that mimics the GHRP‑6 hexapeptide and stimulates growth hormone secretion.
- It synergizes with growth hormone‑releasing hormone (GHRH), enhancing overall GH release.
- The molecule operates via an alternative signal‑transduction pathway distinct from the classic peptide mechanism.
Practical Outcomes
- The discovery suggests a potential oral or non‑injectable alternative to peptide GHRP‑6, which could simplify dosing for biohackers. However, the abstract provides no human safety or dosage data, so any use would be experimental and should be approached with caution. Future studies may clarify its effectiveness and optimal protocols.
Summary
Scientists discovered a small‑molecule drug called L‑692,429 that acts like the peptide GHRP‑6, boosting growth hormone release. It works together with the natural hormone‑releasing factor (GHRH) and uses a different cellular pathway than the peptide. This shows that non‑peptide compounds can mimic GHRP‑6’s effects, which could eventually lead to easier‑to‑use GH‑boosting supplements.
Abstract
A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-([2'-(1H-tetrazol-5 -yl) (1,1'-biphenyl)-4-yl]methyl)-1H-1-benzazepin-3(R)-yl)-butanamid e (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an alternative signal transduction pathway. The mechanism of action of L-692,429 and studies with peptidyl and nonpeptidyl antagonists suggest that this molecule is a mimic of the growth hormone-releasing hexapeptide His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GHRP-6). L-692,429 is an example of a nonpeptidyl specific secretagogue for growth hormone.
Study Information
pubmed
1993
1993-06-11T00:00:00.000Z
10.1126/science.8503009