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GHRP-6

Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

Quick Stats
Studies 702
Trials 0
Overview Studies Clinical Trials
Score 3
1995 pubmed

Hexarelin, a potent GHRP analogue: interactions with GHRH and clonidine in young and aged dogs.

Cella. S G SG; Locatelli. V V; Poratelli. M M; De Gennaro Colonna. V V; Imbimbo. B P BP; Deghenghi. R R; Müller. E E EE

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Key Findings

  • Hexarelin stimulates GH release in dogs, with higher doses causing bigger spikes.
  • When combined with GHRH, hexarelin dramatically amplifies GH secretion in both young and aged dogs.
  • Hexarelin only enhances clonidine‑induced GH release in young dogs; the effect is lost in older dogs, likely due to age‑related loss of GHRH‑producing neurons.

Practical Outcomes

  • For biohackers, hexarelin appears capable of raising GH on its own and can be paired with GHRH analogues for a stronger effect, even in older individuals. However, combining it with clonidine may not add benefit for older users. Because the data are from dogs, human trials are needed before applying these dosing strategies.

Summary

Hexarelin (a GHRP‑6‑like peptide) makes dogs release growth hormone (GH) in a dose‑dependent way. It works together with a GHRH drug to boost GH in both young and old dogs, but it only helps clonidine raise GH in young dogs, suggesting older dogs have a weaker GHRH system.

Abstract

The GH-releasing activity of hexarelin was evaluated in unanesthetized young and aged dogs. Hexarelin (15.6-250 micrograms/kg, i.v.) significantly stimulated GH secretion in a dose-dependent fashion in dogs of both age groups. The ability of hexarelin to potentiate the GH-releasing effect of GHRH (2 micrograms/kg, i.v) and clonidine (4 micrograms/kg, i.v.) was then tested. Hexarelin strikingly potentiated the effect of GHRH both in young and aged dogs, whereas it potentiated the effect of clonidine in young dogs only. Because clonidine acts on the hypothalamus to release GHRH, its failure to synergize with hexarelin in aged dogs is likely due to an age-related impairment of GHRH-secreting neurons.

Study Information

Provider

pubmed

Year

1995

DOI

10.1016/0196-9781(94)00149-z