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Gonadorelin

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH, Factrel

A synthetic decapeptide analog of GnRH that stimulates the pituitary gland to release FSH and LH, aiding in reproductive hormone regulation and fertility treatments.

Molecular Profile
Formula C55H75N17O13
Mol. Weight 1182.3 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Intravenous (IV)
5-20 mcg per pulse
INT
Subcutaneous (SC)
5-20 mcg per pulse
SUB
Intranasal
100-200 mcg
INT

How It Works

How It Works: Gonadorelin mimics natural GnRH by binding to receptors in the anterior pituitary, prompting the release of gonadotropins that regulate reproductive functions.

  • Receptor Binding: Activates GnRH receptors on gonadotroph cells.
  • Gonadotropin Release: Stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
  • Downstream Effects: Enhances gonadal steroid production, supporting ovulation, spermatogenesis, and hormone diagnostics.

Latest Clinical Trials

Recruiting PHASE3 NCT06375811

Pre-IVF Treatment With a GnRH Antagonist in Women With endometriosis_temp

Yale University
INTERVENTIONAL
Updated Dec 15, 2025
Active Not Recruiting PHASE3 NCT05493709

Efficacy, Safety, and Pharmacokinetics of Leuprolide Mesylate in Subjects With Central Precocious Puberty

Foresee Pharmaceuticals Co., Ltd.
INTERVENTIONAL
Updated Dec 15, 2025
Active Not Recruiting PHASE2 NCT05694819

Darolutamide in Patients With Androgen Receptor-Positive Salivary Gland Carcinoma (DISCOVARY)

National Cancer Center Hospital East
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

pubmed Dec 22, 2025

Expression of Sortilin 1-like immunoreactive proteins, an endocytic receptor for pathogenic α-synuclein fibrils, in bovine GnRH neurons: observations in young and aged animals.

Niyonzima. Yvan Bienvenu YB; Wanjiru. Denis Karani DK; Kadokawa. Hiroya H

Researchers found that a protein called sortilin (or similar versions of it) is present in the GnRH‑producing neurons of both young and old cows. The amount of sortilin‑related protein was a bit higher in certain brain regions of older animals, but the gene’s RNA levels didn’t change much with age. The study is mostly basic science and doesn’t give any tips on using gonadorelin or other peptides for health or performance.

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