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Gonadorelin

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH, Factrel

Quick Stats
Studies 192
Trials 100
2025 pubmed

Options for Final Oocyte Maturation Trigger: Can the Ovarian Response Prediction Index (ORPI) Guide the Optimal Choice?

Franco Junior. Jose G JG; Petersen. Claudia G CG; Meziara. Joao Bosco JB; Oliveira. Joao Batista A JBA

Key Findings

  • Error

Practical Outcomes

  • Error

Summary

Error: Timeout.

Abstract

Dual triggering is recommended in most cases with GnRH antagonists for final oocyte maturation. Although no definitive data support the routine use of dual triggering in normal responders, recent meta-analyses have indicated benefits linked to dual triggering regarding improved reproductive outcomes (oocyte maturation, embryo quality, and clinical pregnancy). Therefore, dual triggering may be considered the preferred trigger for all patients undergoing IVF with antagonist blockade cycles (ORPI in ranges A and B (without hCG dose reduction) and in cases of ORPI in ranges C and D (with hCG dose reduction). Finally, rigorous clinical assessment is essential when an isolated GnRHa trigger is combined with low-dose hCG to correct an inadequate luteal phase. In these cases, the freezing all protocol cannot be ignored.

Study Information

Provider

pubmed

Year

2025

Date

2025-12-10T00:00:00.000Z

DOI

10.5935/1518-0557.20250175