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Gonadorelin

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH, Factrel

Quick Stats
Studies 192
Trials 100
Unknown NA INTERVENTIONAL NCT01473459

Comparison Between Two Fertility Protocols in Obese Polycystic Ovary Syndrome Patients

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The purpose of this study is to compare two fertility protocols in obese women with Polycystic Ovarian Syndrome who are candidates for In Vitro Fertilization (IVF). These protocols carry less risk of ovarian hyperstimulation syndrome which these women may experience.

Detailed Description

The purpose of this study is to compare two fertility protocols in obese women with Polycystic Ovarian Syndrome who are candidates for In Vitro Fertilization (IVF). These protocols carry less risk of ovarian hyperstimulation syndrome which these women may experience.The patients in the IVM group will not be exposeD to gonadotropin treatment for controlled ovarian hyperstimulation. In the antagonist group we will use GnRH agonist to induce ovulation which may reduce the risk for ovarian hyperstimulation.

Interventions

Name: IVM (In Vitro Maturation) Treatment
Type: PROCEDURE
Description: There will be no gonadotropin stimulation. There will be ovum pickup from antral follicles of immature oocyte which will be matured in the lab and fertilized by intracytoplasmic sperm injection (ICSI). Embryo transfer will take place on days 2 or 3.
Name: IVF (In Vitro Fertilization) Antagonist Protocol
Type: PROCEDURE
Description: The first stage of the treatment will be stimulation with gonadotropins. Next GNRH Antagonist will be added. Ovulation induction will be performed with GNRH agonist. After ovulation there will be ovum pickup and fertilization in the lab. Embryo transfer will take place on days 2 or 3.

Primary Outcomes

Measure: Fertility results
TimeFrame: One year
Description:

Trial Information

NCT ID

NCT01473459

Status

Unknown

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Hillel Yaffe Medical Center

Last Updated

December 15, 2025