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Gonadorelin

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH, Factrel

Quick Stats
Studies 192
Trials 100
Active Not Recruiting PHASE3 INTERVENTIONAL NCT00223145

Study on the Role of Hormonal Treatment for Two Dosage Levels of Prostate Radiation Therapy Versus Prostate Radiation Therapy Alone

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The hypothesis of the proposed study would be that, due to the six months of total androgen blockade, which would include neoadjuvant hormonal therapy for four months and concomitant hormonal therapy for two months with irradiation, the investigators could reduce local failure rates for these two dosage levels, namely 70 Gy and 76 Gy. Since increasing the dose to the prostate also seems to reduce local relapse rates, the results of the two hormonal therapy groups would be compared with the results of prostate irradiation at doses of 76 Gy. This study would verify the possibility of compensating a six Gy dosage increase of radiation therapy with six months of hormonal therapy between the 70 Gy and 76 Gy groups who received hormonal therapy, and also match these results with a dose escalation to the prostate of 76 Gy. In the future, this could result in more therapeutic choices, such as reducing the doses of radiation therapy and, consequently, its related complications, if hormonal therapy proves to be beneficial; or rather, to continue in the direction of dose escalation for this intermediate-risk patient group, everything being correlated to the side effects of hormonal therapy and irradiation.

Interventions

Name: Radiotherapy 70 Gy
Type: RADIATION
Description: Radiotherapy to the prostate
Name: Radiotherapy 76 Gy
Type: RADIATION
Description: Radiotherapy to the prostate
Name: Androgen blockade
Type: DRUG
Description: Duration : 6 months

Primary Outcomes

Measure: Interval before biochemical failure
TimeFrame: 10 years
Description:

Trial Information

NCT ID

NCT00223145

Status

Active Not Recruiting

Study Type

INTERVENTIONAL

Phases

PHASE3

Sponsor

Abdenour Nabid

Last Updated

December 15, 2025