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Gonadorelin

GnRH, Luteinizing Hormone-Releasing Hormone, LHRH, Factrel

Quick Stats
Studies 192
Trials 100
Unknown OBSERVATIONAL NCT03877185

A New Revolutionary 3-Injection- Protocol in Infertile Women

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

This is a prospective randomised study of the evaluation of the clinical IVF results after following a new revolutionary 3-Injection- Protocol for controlled ovarian stimulation in infertile women.

Detailed Description

A randomized prospective study focusing on infertile women undergoing ovarian stimulation for IVF, using Elonva (corifollitropin alfa) as part of two different stimulation protocols. Women assigned to Protocol A receive a bolus late luteal dose of Degarelix, a new long acting GnRH antagonist, a sole Elonva injection in the evening of day 3 of the cycle, followed by the administration of a single dose of triggering agent (GnRH agonist or hCG a, according to the individual response). Women assigned to Protocol B are administered a single dose of Elonva (corifollitropin alfa) on day 2 of the cycle, followed by daily GnRH antagonist doses, fixed on day 7 of the cycle. Ovulation triggering is the same as in group A, with either GnRH agonist or hCG a, accordingly. Live Birth Rates are estimated for both groups of patients. The number of the formed blastocysts in each group is measured, as well.

Interventions

Name: Live birth rate
Type: DIAGNOSTIC_TEST
Description: Live Birth Rate and Blastulation Rate according to the protocol of COS

Primary Outcomes

Measure: Live birth rate according to stimulation protocol
TimeFrame: Up to 38 weeks after embryo transfer
Description: Live birth rate according to stimulation protocol

Trial Information

NCT ID

NCT03877185

Status

Unknown

Study Type

OBSERVATIONAL

Sponsor

Assisting Nature

Last Updated

December 15, 2025