Does vitamin B12 influence clinical pregnancy outc... - Gonadorelin Study

Key Findings

When vitamin B12 levels are ≤ 358.7 pg/mL, each 10 pg/mL increase is associated with a 4% higher clinical pregnancy rate (OR = 1.04).

The association remains after adjusting for age, BMI, AMH, oocyte count, embryo quality, and number transferred.

The study is retrospective and calls for further validation before clinical use.

Practical Outcomes

For biohackers or self‑experimenters, the finding is not actionable right now. It suggests a possible modest benefit of higher B12 within a low range for IVF outcomes, but no clear protocol or dosage recommendation can be drawn without more evidence.

Summary

A study looked at whether blood vitamin B12 levels affect pregnancy success in IVF cycles that use a GnRH agonist. They found that, within a certain low range of B12, each 10 pg/mL increase was linked to a small (about 4%) rise in clinical pregnancy rates, but the effect was modest and needs more research.

Abstract

To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes. Single-center, retrospective, observational study. Single-center, retrospective, observational study. The primary outcome was the clinical pregnancy rate (CPR). After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03). Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance. None.

Study Information

Provider

pubmed

Year

2025

Date

2025-10-21T00:00:00.000Z

DOI

10.1186/s12884-025-08250-3

References