A study in China gave kids with early puberty a drug called triptorelin (a GnRH agonist) along with special nursing care. The kids who got the extra care did a bit better: more of them improved, they grew taller, had lower hormone levels, showed fewer behavior problems, felt better overall, and had fewer side‑effects than kids who got the standard treatment alone.

This study evaluates clinical efficacy of cluster nursing plus triptorelin in pediatric precocious puberty and its impact on patient quality of life. A total of 110 children with precocious puberty hospitalized between June 2022 and June 2024 were enrolled. To ensure comparability, participants were grouped using propensity score matching based on the nursing method previously received, along with sex, age, and baseline characteristics. The subjects were then randomized into 2 groups: the control group (n = 55), which received standard therapy, and the study group (n = 55), which received cluster nursing plus triptorelin treatment in addition to the standard care regimen. The clinical efficacy, growth and development indicators, children's behavioral problems, quality of life, and the occurrence of adverse reactions were observed and compared between the 2 groups. The total effective rate after intervention was significantly higher in the study group (96.36%) than in the control group (85.45%) (P < .05). After intervention, bone age and predicted adult lifetime high level were increased in both groups compared with before intervention, luteinizing hormone and T were decreased compared with before intervention, the study group demonstrated significantly higher predicted adult height versus controls, while bone age, luteinizing hormone, and T levels were significantly lower versus controls (P < .05). Post-intervention depression scores, social withdrawal, hyperactivity and aggression in both groups were lower than before intervention, and the scores of depression, social withdrawal, hyperactivity, and aggression in the study group were lower than those in the control group (P < .05). After intervention, scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, living environment, anxiety experience, and depression experience in both groups were higher than before intervention, and scores of family life, peer interaction, school life, living environment, self-knowledge, physical emotion, anxiety, and depression scores significantly exceeded control group levels in the study group (P < .05). Post-intervention adverse reaction incidence was 3.64% lower in the study group versus controls (10.91%) (P < .05). The combination of cluster nursing and triptorelin therapy can effectively control the growth and development of children with precocious puberty, improve their behavior problems and quality of life. It has high safety and effectiveness and is worthy of popularization and application.