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Mod GRF 1-29

Sermorelin, Growth Hormone Releasing Hormone (1-29), hGRF(1-29)NH2

A synthetic peptide analog of growth hormone-releasing hormone that stimulates the pituitary gland to secrete growth hormone.

Molecular Profile
Formula C149H246N44O42S
Mol. Weight 3358 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
200-500 mcg
SUB
Intravenous (IV)
1-10 mcg/kg
INT

How It Works

How It Works: GRF(1-29) mimics natural GHRH by binding to specific receptors on pituitary somatotroph cells, triggering a signaling cascade that leads to the pulsatile release of growth hormone.

  • Receptor Binding: Binds to GHRH receptors (GHRHR), activating G-protein coupled pathways.
  • cAMP Increase: Stimulates adenylate cyclase, elevating intracellular cAMP levels.
  • GH Secretion: Promotes calcium influx and exocytosis of growth hormone vesicles from pituitary cells.
  • Feedback Regulation: Subject to negative feedback by somatostatin and IGF-1.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Withdrawn PHASE2 NCT02931474

Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia

National Institute of Nursing Research (NINR)
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT00608023

TH9507 Extension Study in Patients With HIV-Associated Lipodystrophy

Theratechnologies
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE2 NCT01264497

Safety Study of TH9507 in Subjects With Stable, Type 2 Diabetes

Theratechnologies
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 2
pubmed Oct 6, 2023

Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.

Cristea. Cătălina-Diana CD; Radu. Mihai M; Toboc. Ani A; Stan. Crist...

Scientists created a very sensitive urine test that can spot tiny amounts of growth‑hormone‑releasing peptides like sermorelin (GRF‑1‑29). It can detect as little as 0.2 ng/mL, which is far lower than most everyday tests, and it meets anti‑doping standards. For biohackers, this means the test can catch even low‑dose use, but the study doesn’t give any new tips on how to use the peptide safely or effectively.

Utility 2
pubmed Dec 25, 2018

An immuno polymerase chain reaction screen for the detection of CJC-1295 and other growth-hormone-releasing hormone analogs in equine plasma.

Timms. Mark M; Ganio. Katherine K; Forbes. Grace G; Bailey. Simon S; Steel. Roha...

The paper describes a super‑sensitive test that can spot the performance‑enhancing peptide CJC‑1295 in horse blood, even though the drug sticks to plasma proteins and hides from usual mass‑spec methods. It shows the peptide stays in the bloodstream much longer because of this binding, and the new assay can detect it at very low levels.

Browse All Studies