Glycine-modified growth hormone secretagogues identified in seized doping material.
Gajda. Paulina Marta PM; Holm. Niels Bjerre NB; Hoej. Lars Jakobsen LJ; Rasmussen. Brian Schou BS; Dalsgaard. Petur Weihe PW; Reitzel. Lotte Ask LA; Linnet. Kristian K
Key Findings
- Error
Practical Outcomes
- Error
Summary
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Abstract
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1-29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.
Study Information
pubmed
2018
2018-09-11T00:00:00.000Z
10.1002/dta.2489
6
8