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Mod GRF 1-29

Sermorelin, Growth Hormone Releasing Hormone (1-29), hGRF(1-29)NH2

Quick Stats
Studies 227
Trials 47
Overview Studies Clinical Trials
Score 1
1990 pubmed

A glucagon-secretin-like peptide stimulates the intrinsic nervous plexus of guinea pig gallbladder.

Greco. A V AV; Mancinelli. R R; Mingrone. G G; Racanicchi. C C

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Key Findings

  • GRF‑1‑29 dramatically boosts the strength and frequency of gallbladder muscle waves in guinea pigs.
  • A VIP receptor blocker does not change gallbladder tone or activity, indicating VIP isn’t the key neurotransmitter here.
  • The study proposes that a glucagon‑secretin family peptide, not VIP, acts as the intrinsic inhibitory signal in the gallbladder.

Practical Outcomes

  • For biohackers, this research doesn’t provide a clear, safe way to use GRF‑1‑29 for human health. It hints that the peptide could affect gallbladder or gut motility, but the findings are limited to guinea pigs and lack dosage or safety data, so it’s not ready for real‑world protocols.

Summary

In guinea pig gallbladders, a peptide called GRF‑1‑29 (a glucagon‑secretin family member) makes the muscle contract more strongly and often, while blocking VIP (another gut peptide) does nothing. This suggests that the natural nerve signal that relaxes the gallbladder isn’t VIP but something like GRF‑1‑29.

Abstract

The role of vasoactive intestinal peptide (VIP), as a possible neurotransmitter of the intrinsic nerve plexus in the guinea pig gallbladder, was investigated by monitoring spontaneous contractile activity. VIP receptor antagonist (4 Cl-D-Phe6, Leu 17)-VIP did not produce any effect on muscular tone and spontaneous activity, whereas (N-Ac-Tyr1, D-Phe2)-GRF-(1-29)-NH2, (14-GRF analog), which is known to stimulate digestive enzyme secretion by interacting with the VIP-preferring receptors, greatly increased the amplitude and frequency of waves as well as the muscular tone. Since VIP receptor antagonist acts selectively as a competitive antagonist for the action of VIP, we conclude that the gallbladder inhibitory intrinsic plexus neurotransmitter is not VIP, but a member of the glucagon-secretin family of peptides.

Study Information

Provider

pubmed

Year

1990

Date

1990-05-15T00:00:00.000Z

DOI

10.1007/bf01954226