Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat.
Bresciani. E E; Rapetti. D D; Donà. F F; Bulgarelli. I I; Tamiazzo. L L; Locatelli. V V; Torsello. A A
Key Findings
- Obestatin reduces hunger‑driven eating in short‑term starved rats.
- Obestatin does not alter GH secretion in 10‑day‑old rats and does not interfere with hexarelin‑induced GH release.
- Obestatin has no effect on spontaneous corticosterone (stress hormone) secretion.
Practical Outcomes
- For biohackers, this study offers little actionable insight. It shows that obestatin isn’t useful for boosting GH or managing stress hormones, and its appetite‑suppressing effect has only been demonstrated in rats, not humans. Until human data emerge, there’s no clear protocol to adopt.
Summary
In young adult male rats, a gut‑derived peptide called obestatin cuts down food intake after a short fast, but it doesn't change growth‑hormone (GH) or stress‑hormone (corticosterone) levels, and it doesn't block the GH‑boosting action of another peptide, hexarelin.
Abstract
Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.
Study Information
pubmed
2006
10.1007/bf03344175