We are ageing.
Kolovou. Genovefa D GD; Kolovou. Vana V; Mavrogeni. Sophie S
Key Findings
- Aging involves multiple biological pathways including oxidative stress, metabolism, inflammation, DNA repair, and GH/IGF signaling.
- Caloric restriction, TOR inhibition, sirtuin activation, hexarelin, and hormetic stress are highlighted as leading longevity strategies.
- The review summarizes current theories and mechanisms of aging without providing new experimental data on hexarelin.
Practical Outcomes
- Hexarelin is mentioned as a promising anti‑aging peptide, but the article offers no concrete dosing or usage guidelines. For biohackers, it signals that hexarelin may be worth watching, but more detailed research is needed before adding it to a protocol.
Summary
The paper is a broad review of why we age, covering things like oxidative stress, metabolism, inflammation, DNA repair, and growth hormone pathways. It says the most promising ways to extend life right now are things like eating less, targeting the TOR pathway, activating sirtuins, using the peptide hexarelin, and applying hormetic stress. It doesn’t give any specific dosing or protocols for hexarelin, just lists it as a potential anti‑ageing tool.
Abstract
Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
Study Information
pubmed
2014
2014-06-22T00:00:00.000Z
10.1155/2014/808307
30
159