New active series of growth hormone secretagogues.
Guerlavais. Vincent V; Boeglin. Damien D; Mousseaux. Delphine D; Oiry. Catherine C; Heitz. Annie A; Deghenghi. Romano R; Locatelli. Vittorio V; Torsello. Antonio A; Ghé. Corrado C; Catapano. Filomena F; Muccioli. Giampiero G; Galleyrand. Jean-Claude JC; Fehrentz. Jean-Alain JA; Martinez. Jean J
Abstract
New growth hormone secretagogue (GHS) analogues were synthesized and evaluated for growth hormone releasing activity. This series derived from EP-51389 is based on a gem-diamino structure. Compounds that exhibited higher in vivo GH-releasing potency than hexarelin in rat (subcutaneous administration) were then tested per os in beagle dogs and for their binding affinity to human pituitary GHS receptors and to hGHS-R 1a. Compound 7 (JMV 1843, H-Aib-(d)-Trp-(d)-gTrp-formyl) showed high potency in these tests and was selected for clinical studies.(1)
Study Information
pubmed
2003
2003-03-27T00:00:00.000Z
10.1021/jm020985q