EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man.
Broglio. F F; Boutignon. F F; Benso. A A; Gottero. C C; Prodam. F F; Arvat. E E; Ghè. C C; Catapano. F F; Torsello. A A; Locatelli. V V; Muccioli. G G; Boeglin. D D; Guerlavais. V V; Fehrentz. J A JA; Martinez. J J; Ghigo. E E; Deghenghi. R R
Key Findings
- EP1572 binds the growth‑hormone‑secretagogue receptor with similar strength to ghrelin
- A single IV dose of 1 µg/kg caused a strong, selective rise in GH in healthy men
- An oral dose as low as 0.06 mg/kg also reliably increased GH levels
Practical Outcomes
- For biohackers, EP1572 suggests a potentially oral method to stimulate GH, but start with very low doses and track hormone levels. Expect modest effects and be aware that evidence is limited to a few subjects, so use cautiously and await larger studies.
Summary
A new compound called EP1572 (hexarelin) works like the hunger hormone ghrelin and makes the body release growth hormone. In tiny studies it boosted GH when given by IV and even when taken as a pill at very low doses, showing it could be an easy way to raise GH levels. However, the human data are from only two young men, so more research is needed before it can be recommended widely.
Abstract
EP1572 UMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after s.c. administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute i.v. EP1572 administration (1.0 microg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.
Study Information
pubmed
2002
10.1007/bf03345096