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Hexarelin

Examorelin, HEX

Quick Stats
Studies 233
Trials 61
Overview Studies Clinical Trials
Score 3
1994 pubmed

Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep.

Guillaume. V V; Magnan. E E; Cataldi. M M; Dutour. A A; Sauze. N N; Renard. M M; Razafindraibe. H H; Conte-Devolx. B B; Deghenghi. R R; Lenaerts. V V

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Key Findings

  • Hexarelin (1 mg IV) raised blood GH levels within 15 minutes in sheep
  • The rise in GH was linked to a strong increase in GHRH released into the pituitary portal blood
  • Somatostatin levels did not change, indicating the effect is not due to reduced inhibition

Practical Outcomes

  • Hexarelin can act as a fast-acting GH secretagogue, but the effective dose and IV route used in sheep may not translate directly to humans. Biohackers should treat this as mechanistic proof that hexarelin stimulates GH via GHRH, and any dosing protocol will need careful adjustment and safety monitoring.

Summary

A single IV dose of hexarelin in sheep quickly boosted growth hormone levels, mainly by making the brain release more GHRH, while not affecting the hormone that normally blocks GH. This shows hexarelin works not just directly on the pituitary but also by activating brain signals that tell the pituitary to release GH.

Abstract

The acute effect of a new GH-releasing peptide, hexarelin (1 mg, iv), on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep. Peripheral GH levels and GH-releasing hormone (GHRH) and somatostatin concentrations in hypophysial portal blood were measured in six rams. An increase in jugular GH levels was observed 15 min after hexarelin injection (9.1 +/- 1.8 vs. 3.9 +/- 0.8 ng/ml; P < 0.05). This was associated with a stimulation of GHRH release into hypophysial portal blood (145.4 +/- 19.9 vs. 59.2 +/- 10.8 pg/ml; P < 0.01) without a change in somatostatin secretion. Our data indicate that GH-releasing peptide-induced GH stimulation in the sheep involves an activation of GHRH neurons in addition to the previously demonstrated direct effect on the pituitary cells.

Study Information

Provider

pubmed

Year

1994

DOI

10.1210/endo.135.3.7915227