Short term effect of intranasal administration of hexarelin--a synthetic growth hormone-releasing peptide. Preliminary communication.
Frenkel. J J; Silbergeld. A A; Deghenghi. R R; Laron. Z Z
Key Findings
- Intranasal hexarelin for 7 days increased serum IGF‑1 in children.
- Alkaline phosphatase, a marker of bone growth, also rose significantly.
- TSH showed a modest rise within normal limits, with no drop in thyroid hormone.
Practical Outcomes
- The study shows that short‑term nasal hexarelin can boost IGF‑1 and bone‑growth markers, suggesting it has growth‑promoting activity. However, it was done only in children, for a week, and safety data are minimal, so it isn’t a ready‑to‑use protocol for adult biohackers seeking longevity or performance gains.
Summary
A tiny 7‑day study gave kids with normal growth hormone a spray of the peptide hexarelin inside the nose. After a week their blood levels of IGF‑1 (a growth‑related hormone) and alkaline phosphatase went up, and their thyroid‑stimulating hormone rose a little but stayed in the normal range.
Abstract
Twice or three times daily intranasal administration of the hexapeptide hexarelin for 7 days to children with short stature and normal growth hormone (GH) secretion evoked a significant rise in serum levels of insulin-like growth factor-1 (IGF-1) and alkaline phosphatase. There was also a significant, within normal limits, rise of thyroid stimulating hormone (TSH) without evidence of thyroxine suppression.
Study Information
pubmed
1995
10.1515/jpem.1995.8.1.43