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Recruiting PHASE3 INTERVENTIONAL NCT06641791

Palliative Steroeotactic Body Radiotherapy vs Palliative Standard Radiotherapy in Patients With Advanced Head and Neck Cancer

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

This study is being done to answer the following question: Does stereotactic body radiation therapy (SBRT) provide better cancer control compared to standard radiation therapy (RT) for those with advanced head and neck cancer?

Detailed Description

Stereotactic body radiation therapy, or SBRT, is a cancer treatment that more precisely delivers radiation to the tumour area with less radiation going to unaffected areas around the tumour. It uses fewer treatments of higher doses compared to standard radiation therapy. This study is being done to find out if this approach is better than the usual approach for advanced head and neck cancer. The usual approach is defined as care most people get for advanced head and neck cancer.

Interventions

Name: Standard Radiotherapy (SRT)
Type: RADIATION
Description: 2400 cGy in 3 fractions - day 0/7/21, OR, 2500 cGy in 5 fractions over 1 week
Name: Stereotactic Body Radiotherapy (SBRT)
Type: RADIATION
Description: 4500 cGy in 5 fractions (twice a week to primary and nodal GTV, OR, 4000 cGy in 5 fractions twice a week if organs at risk.

Primary Outcomes

Measure: Overall Survival estimated according to Kaplan-Meier's methodology
TimeFrame: 6 years
Description:

Trial Information

NCT ID

NCT06641791

Status

Recruiting

Study Type

INTERVENTIONAL

Phases

PHASE3

Sponsor

Canadian Cancer Trials Group

Last Updated

December 15, 2025