A New Antioxidant Marker in Cord Blood of Fetuses with Late Fetal Growth Restriction: Humanin.
Kose. Caner C; Korpe. Busra B; Yakut Yucel. Kadriye K; Arat. Ozgur O; Bucak. Mevlut M; Engin Ustun. Yaprak Y
Key Findings
- Humanin levels were higher in fetuses with late fetal growth restriction
- Humanin levels did not correlate with Doppler blood flow measurements
- Higher Humanin was associated with increased NICU admissions
Practical Outcomes
- For the biohacker community, this research offers no immediate actionable insight. Humanin is being explored as a potential biomarker for fetal growth issues, not as a supplement or therapy for longevity, metabolism, or performance in adults. More studies are needed before any practical protocols can be considered.
Summary
The study found that babies with late fetal growth restriction have higher levels of the peptide humanin in their umbilical cord blood, and those higher levels were linked to a greater chance of needing intensive care after birth. This doesn’t tell us how to use humanin for health or performance in adults.
Abstract
<b>Purpose:</b> This study investigated the Humanin levels in the umbilical cord blood of fetuses with late fetal growth restriction (FGR) and -evaluated their association with perinatal outcomes. <b>Materials and Methods:</b> A total of 95 single pregnancies between 32-41 wk (45 with late FGR and 50 controls) were included. Doppler parameters, birth weight and the need for neonatal intensive care unit admission (NICU) were assessed. Correlations between Humanin levels and these parameters were analyzed. <b>Results:</b> Higher Humanin levels were found in fetuses with late FGR compared to the control group (<i>p</i> < 0.05). No significant correlation was observed between Humanin levels and Doppler parameters. Elevated Humanin levels were associated with an increased need for NICU (<i>p</i> < 0.05). <b>Conclusions:</b> The statistically higher levels of Humanin in fetuses with late FGR may suggest the potential of Humanin as an indicator of late FGR. Further research is needed to explore the clinical utility of Humanin.
Study Information
pubmed
2023
2023-06-27T00:00:00.000Z
10.1080/15513815.2023.2229432
1
26