Mitochondrial-Derived Peptides in Diabetes and Its Complications.
Wu. Ying Y; Sun. Liankun L; Zhuang. Zhoudao Z; Hu. Xiaoqing X; Dong. Delu D
Key Findings
- Humanin improves insulin sensitivity in diabetic models
- Humanin reduces inflammatory responses
- Humanin shows anti‑apoptotic effects that may protect against stroke and myocardial infarction
Practical Outcomes
- Humanin looks promising as a supplement to support metabolic health and guard against diabetes‑related complications, but the research is still early and no dosing guidelines exist. Enthusiasts might watch for clinical trials or emerging formulations, but should treat it as experimental for now.
Summary
Humanin, a tiny protein made by mitochondria, appears to help lower insulin resistance, calm inflammation, and protect cells from dying, which could be useful for people with diabetes and for preventing related problems like strokes and heart attacks.
Abstract
The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides.
Study Information
pubmed
2022
2022-02-03T00:00:00.000Z
10.3389/fendo.2021.808120
30
63