The paper describes a computer‑based system that combines human input with AI to predict coma using brain‑wave data, but it does not discuss the peptide humanin or any health‑optimizing protocols for longevity, metabolism, or performance.

The human-in-the-loop cyber-physical system provides numerous solutions for the challenges faced by the doctors or medical practitioners. There is a linear trend of advancement and automation in the medical field for the early diagnosis of several diseases. One of the critical and challenging diseases in the medical field is coma. In the medical research field, currently, the prediction of these diseases is performed only using the data gathered from the devices only; however, the human's input is much essential to accurately understand their health condition to take appropriate decision on time. Therefore, we have proposed a healthcare framework involving the concept of artificial intelligence in the human-in- the-loop cyber-physical system. This model works via a response loop in which the human's intention is concluded by gathering biological signals and context data, and then, the decision is interpreted to a system action that is recognizable to the human in the physical environment, thereby completing the loop. In this paper, we have designed a model for early prognosis of coma using the electroencephalogram dataset. In the proposed approach, we have achieved the best results using a statistical learning algorithm called autoregressive integrated moving average in comparison to artificial neural networks and long short-term memory models. In order to measure the efficiency of our model, we have used the root mean squared error (RMSE), mean absolute error (MAE), and mean squared error (MSE) value to evaluate the linear models as it gives the difference between the measured value and true or correct value. We have achieved the least possible error value for our dataset. To conduct this experiment, we used the dataset available in the phsyionet opensource community.