Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease.
Eltermaa. Mall M; Jakobson. Maili M; Utt. Meeme M; Kõks. Sulev S; Mägi. Reedik R; Starkopf. Joel J
Key Findings
- SNP rs6151662 in MTRNR2L2 showed a nominal p‑value of 0.0037 but was not significant after multiple‑testing correction
- The best single‑gene signal, rs78083998 in MTRNR2L13, had a nominal p‑value of 0.042 and also failed correction
- No expression‑quantitative trait loci (eQTL) in these regions were significantly associated with coronary artery disease
Practical Outcomes
- For biohackers, this means that looking at your own DNA for humanin‑related variants won’t help predict or prevent heart disease. There’s no current genetic basis to tailor humanin supplementation for CAD risk, so focus on other proven lifestyle or supplement strategies.
Summary
The study checked whether common genetic differences in humanin‑related genes affect heart disease risk and found no solid link after proper statistical correction.
Abstract
Coronary artery disease contributes to noncommunicable disease deaths worldwide. In order to make preventive methods more accurate, we need to know more about the development and progress of this pathology, including the genetic aspects. Humanin is a small peptide known for its cytoprotective and anti-apoptotic properties. Our study looked for genomic associations between humanin-like nuclear isoform genes and coronary artery disease using CARDIoGRAMplusC4D Consortium data. Lookup from meta-analysis datasets gave single nucleotide polymorphisms in all 13 humanin-like nuclear isoform genes with the lowest P value for rs6151662 from the MTRNR2L2 gene including the 50 kb flanking region in both directions (P-value = 0.0037). Within the gene region alone the top variant was rs78083998 from the MTRNR2L13 region (meta-analysis P-value = 0.042). None of the found associations were statistically significant after correction for multiple testing. Lookup for expression trait loci in these gene regions gave no statistically significant variants.
Study Information
pubmed
2019
2019-11-21T00:00:00.000Z
10.1186/s13104-019-4807-x
10
43