Role of the mitochondrial stress response in human cancer progression.
Wang. Sheng-Fan SF; Chen. Shiuan S; Tseng. Ling-Ming LM; Lee. Hsin-Chen HC
Key Findings
- Mitochondrial dysfunction is linked to cancer progression
- Humanin is one of several mitochondria‑derived molecules that can signal to the cell nucleus
- Targeting mitochondrial stress responses is proposed as a potential cancer therapy
Practical Outcomes
- For now there’s no actionable protocol for using humanin to boost health or fight cancer. The review highlights a research direction, but biohackers should wait for human trials before considering supplementation.
Summary
The paper reviews how messed‑up mitochondria can help cancers grow and lists several mitochondrial signals—including the peptide humanin—that might drive this process. It suggests that blocking these signals could be a way to treat cancer, but it doesn’t give any concrete humanin dosing or lifestyle tips.
Abstract
Dysregulated mitochondria often occurred in cancers. Mitochondrial dysfunction might contribute to cancer progression. We reviewed several mitochondrial stresses in cancers. Mitochondrial stress responses might contribute to cancer progression. Several mitochondrion-derived molecules (ROS, Ca<sup>2+</sup>, oncometabolites, exported mtDNA, mitochondrial double-stranded RNA, humanin, and MOTS-c), integrated stress response, and mitochondrial unfolded protein response act as retrograde signaling pathways and might be critical in the development and progression of cancer. Targeting these mitochondrial stress responses may be an important strategy for cancer treatment.
Study Information
pubmed
2020
2020-04-23T00:00:00.000Z
10.1177/1535370220920558
37
273