Assay Development and Measurement of the Aging Biomarker Humanin.
Miller. Brendan B; Wan. Junxiang J
Key Findings
- Humanin is a 24‑amino‑acid mitochondrial peptide associated with aging phenotypes.
- The researchers developed and validated an ELISA that reliably quantifies humanin in biological fluids.
- The assay enables monitoring of humanin level changes in response to interventions.
Practical Outcomes
- The new test means you could have your humanin levels measured by a lab, giving a concrete biomarker to gauge the impact of diet, exercise, or supplementation. You’ll need to find a service that offers the assay, and the numbers will still require careful interpretation.
Summary
Scientists have created a straightforward blood test (ELISA) that can measure humanin, a tiny peptide linked to aging and many health traits. This lets you potentially track your own humanin levels to see how lifestyle changes or supplements affect it.
Abstract
Biomarkers that reflect aging could be used to target age-related diseases with precision and monitor treatment efficacy. One such biomarker is humanin, a 24-amino acid mitochondrial-derived peptide encoded within the mitochondrial 16S rRNA gene. Humanin is measured in biological fluids, associates with many aging phenotypes, and attenuates aging in several animal models. In this chapter, we highlight the development and protocol of an enzyme-linked immunosorbent assay that quantifies humanin levels in biological fluid.
Study Information
pubmed
2020
10.1007/978-1-0716-0592-9_18
3
16